Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Comparable efficacy to that of IV iron sucrose. Formula for calculating the required dose of iron sucrose 1. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). If you log out, you will be required to enter your username and password the next time you visit. Applies only to oral form of both agents. A healthcare provider will give you this injection. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. For liquid medications, also enter the value of the Medicine Concentration and choose . Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Do not administer Venofer to patients with evidence of iron overload. Use Caution/Monitor. If we don't have the calculator you need then tell us the details and we'll make it for you. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Do not administer Venofer to patients with iron overload. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Use alternatives if available. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Avoid or Use Alternate Drug. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Modify Therapy/Monitor Closely. Ganzoni Equation for Iron Deficiency Anemia - MDCalc Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Separate dosing of tetracyclines from these products. Applies only to oral form of both agents. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Our dosage calculator can help you with this as well. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Applies only to oral form of both agents. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Applies only to oral form of both agents. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to LBW = Lean body weight in kg. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Use Caution/Monitor. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Minor/Significance Unknown. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Use Caution/Monitor. Do Not Copy, Distribute or otherwise Disseminate without express permission. Venofer (iron sucrose) dosing, indications, interactions, adverse iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Minor/Significance Unknown. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Shirley, NY: American Regent, Inc.; 9/2020. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Intravenous iron therapy for patients with anemia Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Applies only to oral form of both agents. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Intravenous iron-dextran: therapeutic and experimental possibilities. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Interaction only with oral iron administration. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Either decreases levels of the other by inhibition of GI absorption. Minor/Significance Unknown. Applies only to oral form of both agents. Discard unused portion. Creating an account is free and takes less than 1 minute. Generic name: IRON SUCROSE 20mg in 1mL Pregnancy: Risk Summary-Clinical Considerations. This cost includes the fee charged by the pharmacy. Use Caution/Monitor. elemental iron (mg/ml) in the product being used: Where C= Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Venofer has not been studied in patients younger than 2 years old. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Iron Sucrose Monograph for Professionals - Drugs.com Ferric gluconate: 12.5 mg/mL. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Your doctor will do laboratory tests to monitor your response. Either increases effects of the other by pharmacodynamic synergism. Separate dosing of tetracyclines from these products. Iron Deficiency in Heart Failure - Home - American College of Cardiology Clinical calculators for obstetrics and gynaecology - calculosaurus Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Aranesp (darbepoetin alfa) | Dosing Considerations Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Venofer (iron sucrose) dose calculator | Calculosaurus.com Before using, check this product visually for particles or discoloration. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Mean change in Hgb from baseline to Week 5 2,5 Do Not Copy, Distribute or otherwise Disseminate without express permission. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. commonly, these are "non-preferred" brand drugs. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Use Caution/Monitor. Deferoxamine chelates iron. Applies only to oral form of both agents. May increase risk of hypotension. Your doctor will do laboratory tests to monitor your response. Minor/Significance Unknown. https://www.uptodate.com/ (Requires subscription). Minor/Significance Unknown. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. Applies only to oral form of both agents. The dosage of iron sucrose is expressed in mg of elemental iron. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com iron sucrose, captopril. DICP. Anemia caused by the depletion of iron is called iron deficiency anemia. This drug is available at a higher level co-pay. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Avoid or Use Alternate Drug. PDF Highlights of Prescribing Information Contraindications- Venofer Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Administer on 5 different occasions over a 14 day period. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Use Caution/Monitor. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Venofer may cause clinically significant hypotension. In the text below the tool there is more information on how the iron deficit is calculated. All Rights Reserved. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Use Caution/Monitor. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. It can be expressed in mg per ml. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Iron sucrose: 20 mg/mL. MISSED DOSE: It is important to get each dose of this medication as scheduled. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Applies only to oral form of both agents. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Use Caution/Monitor. Each mL contains 20 mg of elemental . Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Applies only to oral form of both agents. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . This topic . Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. One dose IV Iron replacement | Monoferric Minor/Significance Unknown. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Use Caution/Monitor. Modify Therapy/Monitor Closely. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Accessed: 4/12/2011. US residents can call their local poison control center at 1-800-222-1222. Parenteral iron supplementation. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Administer Venofer early during the dialysis session (generally within the first hour). Use Caution/Monitor. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. 1970;100(7):301303. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Fulminant symptoms include confusion, sensation of passing out, paleness. Included in the iron dextran package insert. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Applies only to oral form of both agents. 1990 Feb;24(2):162-6. Use Caution/Monitor. Iron deficiency anemia is the type of anemia caused by iron depletion. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Use Caution/Monitor. This website is intended for use by US healthcare professionals only. Do not double the dose to catch up. Below the form there are further instructions on how to use the calculator. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Separate by at least 4 hours. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. 2015: 763576. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Burns DL, Mascioli EA, Bistrian BR. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Medically reviewed by Drugs.com. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Use Caution/Monitor. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Applies only to oral form of both agents. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. IDA diagnosis is based on full blood examination and on the serum ferritin level. Applies only to oral form of both agents. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com This document does not contain all possible drug interactions.

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