Occurrence is more common among patients with alcoholism, undernutrition, or other chronic debilitating illness. During treatment of hyponatremia, serum sodium should not be elevated by more than 10 to 12 mEq/L in 24 hours, or 18 mEq/L in 48 hours. Take your Lithium carbonate tablets exactly as prescribed by your healthcare provider. Treatment Tell your doctor about all your current medicines. See Table 2 for Lithium carbonate and Lithium oral solution dose conversion. Before taking Lithium carbonate tablets, tell your healthcare provider if you: Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. Impairment of Fertility. You may report side effects to FDA at 1-800-FDA-1088. Lithium may prolong the effects of neuromuscular blocking agents. Such patients should be carefully managed to avoid dehydration with resulting Lithium retention and toxicity. -Regular release formulations: 600 mg orally 3 times a day, in the morning, afternoon, and nighttime Changing your salt intake could change the amount of lithium in your blood. Avoid becoming overheated or dehydrated during exercise and in hot weather. No specific antidote for Lithium poisoning is known [see Overdosage (10)]. Routine urinalysis and other tests may be used to evaluate tubular function (e.g., urine specific gravity or osmolality following a period of water deprivation, or 24-hour urine volume) and glomerular function (e.g., serum creatinine, creatinine clearance, or proteinuria). Lithium (mean serum level 0.98 ± 0.47 mEq/L) was statistically significantly superior to placebo in decreasing acute mania or mixed states as measured by the YMRS (see Table 5). People who have unexplained fainting or who have a family history of sudden unexplained death before 45 years of age may have Brugada Syndrome and not know it. Lithium affects the flow of sodium through nerve and muscle cells in the body. In this study, Lithium was administered at daily doses ranging from 300 to 3600 (mean dose 1483 mg ± 584) with serum levels ranging from 0 to 2.0 (mean level 0.98 mEq/L ± 0.47). There have been no adequate studies performed in animals at current standards to evaluate the effect of Lithium treatment on fertility. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Store Lithium carbonate tablets at room temperature, between 68°F to 77°F (20°C to 25°C). The background risk of major birth defects and miscarriage for the indicated population(s) is unknown. -Regular release formulations: 300 mg orally 3 to 4 times a day Dose Adjustments During Pregnancy and the Postpartum Period: If the decision is made to continue Lithium treatment during pregnancy, serum Lithium concentrations should be monitored and the dosage adjusted during pregnancy. Cardiac manifestations involve electrocardiographic changes, such as prolonged QT interval, ST and T-wave changes and myocarditis. Change From Baseline at Week 8 in YMRS Summary Score. ISS. Lithium should be avoided in patients with Brugada Syndrome or those suspected of having Brugada Syndrome. Bottles of 100’s with Child Resistant Cap……………NDC 62756-430-88 False hypercalcemia due to plasma volume depletion resulting from nephrogenic diabetes insipidus should be excluded in individuals with mildly increased serum calcium. Nausea and general discomfort may also appear during the first few days of Lithium administration. Lithium is in a class of medications called antimanic agents. Take your Lithium carbonate tablets exactly as your healthcare provider tells you to take it. Fine hand tremor, polyuria, and thirst may occur during initial therapy for the acute manic phase and may persist throughout treatment. Keep the bottle tightly closed when not in use. CTIN patients might present with nephrotic proteinuria (>3.0g/dL), worsening renal insufficiency and/or nephrogenic diabetes insipidus. Total reliance must not be placed on serum concentrations alone. Serotonin Syndrome, Caution patients about the risk of serotonin syndrome, particularly with the concomitant use of Lithium with other, serotonergic drugs including SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, tramadol, tryptophan, buspirone, St. John’s Wort, and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid) [see Warnings and Precautions (5.6) and Drug Interactions (7)]. Subsequent case-control and cohort studies indicate that the increased risk for cardiac malformations is likely to be small; however, the data are insufficient to establish a drug-associated risk. Your healthcare provider will do certain blood tests before starting and during treatment with Lithium carbonate tablets. Pills, check interactions and set up your own personal medication records detail ) be completely absorbed in upper... 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